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A pinch of salt, a splash of milk and a handful of raisins. A measurement is sometimes based on instinct. Grandma's recipes are not precise, and a baker seems to know exactly how much flour he needs. But, just a drop of dishwashing liquid in your bowl and your egg whites won’t stiffen. Sometimes a tiny amount of something is a matter of life or death. How much insulin should you inject after a meal? How does an anaesthetist determine how much anaesthetic you should be given during an operation? The measurement of some things is vital, whether it's macaroons or medication.